Gene information
Official symbol SERPINC1
Official full name serpin family C member 1
Gene type protein-coding gene
Chromosome1q25.1
Alias symbolATIII; MGC22579
Previous symbolAT3
Gene familySerpin peptidase inhibitors
Resources
Entrez Gene 462
HGNC HGNC:775
Ensembl ENSG00000117601
Vega OTTHUMG00000037276
UCSC uc001gjt.4
GO terms: 34 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 23 records
Drug name Interaction type Source PMID View
antithrombin alfa TTD view
ardeparin sodium activatorpotentiator ChemblInteractions 76329441239736711287128 view
avatrombopag PharmGKBFDA view
carboplatin PharmGKB 31616045 view
dalteparin sodium activator ChemblInteractions view
danaparoid sodium activator ChemblInteractions view
delparantag TTD 22315264 view
eltrombopag PharmGKBFDA view
enoxaparin activatorpotentiator TENDTTD 19888521174896641668694516207425 view
enoxaparin sodium activator ChemblInteractions view
estradiol FDA view
fondaparinux potentiatoractivator TdgClinicalTrialTEND 12501872153174041238303912383040 view
fondaparinux sodium activator ChemblInteractions view
gemcitabine PharmGKB 31616045 view
heparin activatorpotentiator TdgClinicalTrialTEND 1020137117201083175370591981877311278930176007861175235220816747 view
heparin calcium activator ChemblInteractions view
heparin sodium activator ChemblInteractions view
lusutrombopag PharmGKBFDA view
progesterone FDA view
semuloparin sodium inhibitor ChemblInteractions view
sulodexide potentiator TdgClinicalTrialTENDTTD 11752352128182599436179 view
tinzaparin potentiatoractivator TdgClinicalTrial 198885211576798015567452 view
tinzaparin sodium activator ChemblInteractions view
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
NM_000488.4:c.1246G>T genomics myocardial infarction[diagnosis] myocardial infarction Roldan V et al. Thromb Haemost. 2009
antithrombin-III proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Zhu JZ et al. Zhonghua Nei Ke Za Zhi. 1991
antithrombin-III proteomics death[prognosis (bad)] acute myocardial infarction Zhu JZ et al. Zhonghua Nei Ke Za Zhi. 1991
antithrombin-III proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Vonica A et al. Med Interne. 1990
antithrombin-III proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Moyssakis I et al. Blood Coagul Fibrinolysis. 2010
antithrombin-III proteomics cerebral infarction[prognosis (bad)] acute myocardial infarction Chen J et al. Eur Rev Med Pharmacol Sci. 2019
thrombin antithrombin complex proteomics ischemic cardiac events[prognosis (bad)] acute ST elevation myocardial infarction Scharfstein JS et al. Am J Cardiol. 1996
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